SoHo is shorthand for south of Houston (pronounced "how-stun"). It is the first official acronym given to a neighborhood in NYC.
The official historical district from 1973 together with Houston to the north, is north of Canal Street, and between West Broadway and Crosby Streets.

This most diverse neighborhood in lower Manhattan has had a long history before becoming the heart and soul of New York City
All of these reasons make SoHo the heart and soul of New York City.
It is also the backdrop for movie locations, fashion shoots, and one of the best places in the city
to catch a glimpse of famous stars of many genres, many of whom live in SoHo.
It's look and feel has been copied in many movie lots. SoHo has been used as a location
to such movies as Men In Black (Will Smith), Ghost (Demi Moore, Patrick Swyze),
Unfaithful (Diane Lane, Richard Gere), Hitch (Will Smith, Eva Mendez),
Little Nicky (Adam Sandler), Spiderman (Tobey Maguire. Kirsten Dunst),
Raising Helen (Kate Hudson, Garry Marshall Director), After Hours (Griffin Dunne,
Martin Scorcese Director), plus many many more.